Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Identifieur interne : 000238 ( an2020/Analysis ); précédent : 000237; suivant : 000239Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Auteurs : Yongyu Chen [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Jixiang Zhang [République populaire de Chine] ; Pan Cao [République populaire de Chine] ; Wenhao Su [République populaire de Chine] ; Yunchao Deng [République populaire de Chine] ; Na Zhan [République populaire de Chine] ; Xiangsheng Fu [République populaire de Chine] ; Yun Huang [États-Unis] ; Weiguo Dong [République populaire de Chine]Source :
- Theranostics [ 1838-7640 ] ; 2020.
Abstract
Url:
DOI: 10.7150/thno.38870
PubMed: 31903123
PubMed Central: 6929621
Affiliations:
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PMC:6929621Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Fusobacterium nucleatum</italic> Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression</title><author><name sortKey="Chen, Yongyu" sort="Chen, Yongyu" uniqKey="Chen Y" first="Yongyu" last="Chen">Yongyu Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de 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of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Xiangsheng" sort="Fu, Xiangsheng" uniqKey="Fu X" first="Xiangsheng" last="Fu">Xiangsheng Fu</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Gastroenterology, The Affiliated Hospitalof North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong City 637000, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, The Affiliated Hospitalof North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong City 637000</wicri:regionArea><wicri:noRegion>Nanchong City 637000</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yun" sort="Huang, Yun" uniqKey="Huang Y" first="Yun" last="Huang">Yun Huang</name><affiliation wicri:level="1"><nlm:aff id="A5">Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX77030, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX77030</wicri:regionArea><wicri:noRegion>TX77030</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31903123</idno><idno type="pmc">6929621</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929621</idno><idno type="RBID">PMC:6929621</idno><idno type="doi">10.7150/thno.38870</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000824</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000824</idno><idno 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Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Xiangsheng" sort="Fu, Xiangsheng" uniqKey="Fu X" first="Xiangsheng" last="Fu">Xiangsheng Fu</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Gastroenterology, The Affiliated Hospitalof North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong City 637000, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, The Affiliated Hospitalof North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong City 637000</wicri:regionArea><wicri:noRegion>Nanchong City 637000</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yun" sort="Huang, Yun" uniqKey="Huang Y" first="Yun" last="Huang">Yun Huang</name><affiliation wicri:level="1"><nlm:aff id="A5">Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX77030, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX77030</wicri:regionArea><wicri:noRegion>TX77030</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province</wicri:regionArea><wicri:noRegion>Hubei Province</wicri:noRegion></affiliation></author></analytic><series><title level="j">Theranostics</title><idno type="eISSN">1838-7640</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Aims</bold>: We aimed to measure the abundance of <italic>Fusobacterium nucleatum</italic> (<italic>F. nucleatum</italic>) in colorectal cancer (CRC) tissues from patients and to uncover the function of this bacterium in colorectal tumor metastasis.</p><p><bold>Methods</bold>: We collected metastatic and non-metastatic CRC tissues to analyze <italic>F. nucleatum</italic> abundance. Cells were incubated with <italic>F. nucleatum</italic> or chloroquine (CQ) or were transfected with CARD3-targeting siRNA; the expression of mRNAs and proteins was then measured. CRC cells stably transfected with shRNA-luc were mixed with <italic>F. nucleatum</italic> and intravenously injected into BALB/cJ mice. APC<sup>Min/+</sup>, CARD3<sup>-/-</sup>and CARD3<sup>wt</sup> C57BL mice were given <italic>F. nucleatum</italic>; some mice were given azoxymethane (AOM) and dextran sodium sulfate (DSS).</p><p><bold>Results</bold>: <italic>F. nucleatum</italic> was abundant in CRC tissues from patients with metastasis. <italic>F. nucleatum</italic> infection increased CRC cell motility and upregulated the expression of CARD3, LC3-II, Beclin1 and Vimentin, and downregulated the expression of E-cadherin and P62 in CRC cells. These effects were attenuated by treatment with CQ, siCARD3 or both. APC<sup>Min/+</sup> mice gavaged with <italic>F. nucleatum</italic> developed more aggressive tumors than control mice. After AOM/DSS administration, the colorectums of CARD3<sup>-/-</sup> mice had fewer tumors than those of control mice. Tumors from CARD3<sup>-/-</sup> mice had lower levels of LC3-II and Beclin1 and higher levels of P62 than those from control mice. BALB/cJ mice injected with both CT26-luc cells and <italic>F. nucleatum</italic> formed more metastases than control mice. CQ treatment, CARD3 knockdown or both reduced the ability of CT26-luc cells to form metastases <italic>in vivo</italic>.</p><p><bold>Conclusions</bold>: <italic>F. nucleatum</italic> is enriched in CRC tissues from patients with metastasis. <italic>F. nucleatum</italic> orchestrates CARD3 and autophagy to control CRC metastasis. 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uniqKey="Li H">H Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Yongyu" sort="Chen, Yongyu" uniqKey="Chen Y" first="Yongyu" last="Chen">Yongyu Chen</name></noRegion><name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name><name sortKey="Cao, Pan" sort="Cao, Pan" uniqKey="Cao P" first="Pan" last="Cao">Pan Cao</name><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Chen, Yongyu" sort="Chen, Yongyu" uniqKey="Chen Y" first="Yongyu" last="Chen">Yongyu Chen</name><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name><name sortKey="Deng, Yunchao" sort="Deng, Yunchao" uniqKey="Deng Y" first="Yunchao" last="Deng">Yunchao Deng</name><name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name><name sortKey="Dong, Weiguo" sort="Dong, Weiguo" uniqKey="Dong W" first="Weiguo" last="Dong">Weiguo Dong</name><name sortKey="Fu, Xiangsheng" sort="Fu, Xiangsheng" uniqKey="Fu X" first="Xiangsheng" last="Fu">Xiangsheng Fu</name><name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name><name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name><name sortKey="Su, Wenhao" sort="Su, Wenhao" uniqKey="Su W" first="Wenhao" last="Su">Wenhao Su</name><name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name><name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name><name sortKey="Zhan, Na" sort="Zhan, Na" uniqKey="Zhan N" first="Na" last="Zhan">Na Zhan</name><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name><name sortKey="Zhang, Jixiang" sort="Zhang, Jixiang" uniqKey="Zhang J" first="Jixiang" last="Zhang">Jixiang Zhang</name></country><country name="États-Unis"><noRegion><name sortKey="Huang, Yun" sort="Huang, Yun" uniqKey="Huang Y" first="Yun" last="Huang">Yun Huang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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